Human Heart Shape Analysis Pipeline
Average ventricular shapes (templates) were constructed for end-systole
and end-diastole cardiac phases
Pipeline
Image Acquisition Protocol
Each subject was studied in a 64-detector MDCT scanner. Imaging was
performed using a retrospectively electrocardiogram gated MDCT protocol
with the following parameters: gantry rotation time = 400 ms; detector
collimation = 0.5 mm 32 (plane resolution varied from 0.36 mm x 0.36 mm
to 0.45 x 0.45 mm, thickness = 0.5 mm). Axial images were reconstructed
using a multi-segment reconstruction algorithm at 10 time points (the
center of the reconstruction window between 0% and 90% of the cardiac
cycle, at 10% intervals).
Subjects
All patients had left ventricular ejection fraction (LVEF) < 35% on the
basis of a clinically indicated non-MRI study, and all patients had
undergone coronary angiography. Patients were classified as (non-ischemic
cardiomyopathy) NICM if they had no history of myocardial infarction (MI)
or revascularization, and no evidence of coronary artery stenosis > 50% of
2 or more epicardial vessels or left main or proximal left anterior
descending (LAD) coronary artery stenosis > 50%. Patients with
significant coronary LAD artery stenosis and a history of anterior MI were
classified as having ischemic cardiomyopathy (ICM).